Biochips widely used in clinical medicine

In biochips, biological probes are placed on a piece of nail-sized glass slide, silicon wafer, nylon membrane, etc. It first reacts with the sample to be tested, then collects signals related to the reaction result, and finally uses a computer or Other methods analyze the data results. The research of new diagnostic medical technologies centered on biochips has become one of the research hotspots in countries around the world.

The research team of Beijing National Engineering Research Center, a biochip led by academician Cheng Jing of the Chinese Academy of Engineering, has obtained numerous scientific research results and achieved the first export of Chinese biochip technology to the United States.

Applicable prospects It is expected that after nearly 20 years of innovation and efforts, a number of chips for genes and proteins have been successfully developed in various countries around the world. Through clinical verification, more and more hospitals are used in routine inspections.

Gene microarray chip is the most widely used and most widely used type of chip at present. In addition to familiar DNASNP analysis and mutation detection, the analysis of various RNA expression changes has gradually become familiar to the inspectors.

Protein microarray chip is another kind of chip after the application surface is only next to the gene microarray chip, and it can conveniently and quickly detect small molecule drugs, protein molecules in the sample, and autoantibodies.

Microfluidic chip and optical code-based microparticle chip technology are new recruits for clinical testing applications. They can be widely used in the detection of various biomolecules, and their prospects are promising.

Chips based on cell detection are the slowest but most attractive products. Their function can be extended from the separation of cells in samples to the detection of dynamically changing information using cells as the target. The implementation can be either micro The array chip form can also be in the form of a microfluidic chip.

In the future, it is expected that there will be more chip products based on single-molecule sequencing, chip products based on polysaccharide detection, and chip and chip laboratories based on routine detection of biochemical and blood indicators. These will enable our central laboratory to inspect and The side detection project has been greatly enriched. It is believed that in the future, biochips will enter the clinical application faster and faster, and they will inevitably bring good news to predictive medicine, preventive medicine, and individualized therapeutic fields.