Recently, graphene biosensor manufacturer Nanomedical Diagnostics has introduced a new hydrophobic immobilized biosensor, FLEX, which can be combined with the company's Agile R100 non-labeled personal assay system.

Intrinsic membrane proteins (IMPs) are not only difficult to extract from cell membranes, but also have typical instability, which makes the study of IMP extremely challenging. The surface chemistry of biosensors usually needs to be customized according to the unique requirements of each IMP, so a lot of measurement development has to be done. Graphene biosensors accelerate the development of drugs and biotherapies. According to Memes Consulting, Nanomedical Diagnostics, the world's leading graphene biosensor manufacturer, recently introduced a new hydrophobic solid-load biosensor, FLEX, which can be combined with the company's Agile R100 non-labeled personal assay system. This new biosensor accelerates surface chemistry customization, reducing the time required for IMP researchers to obtain reliable in vitro kinetic data.

New FLEX Agile R100 Biosensor

Ross Bundy, CEO of Nanomedical Diagnostics, explains: "The FLEX biosensor provides a flat, highly consistent hydrophobic surface that quickly fixes the film's composition, eliminating the need for time-consuming and error-prone linkers. Linker Chemistry. Because the FLEX biosensor eliminates the need for labeling and labeling steps, it eliminates a lot of finishing work and allows direct determination of native proteins. This makes the assay more flexible than ever, while also having all proteins and membranes fixed. The 'super ability' of the fraction or the lipid monolayer."

Combining this new biosensor with the Agile R100 kinetic characterization platform, which requires less sample and material requirements, makes it easy to study even small amounts of target proteins. When the two are combined, the unprecedented consistency of the hydrophobic surface can improve the reliability of the data, and the elimination of the label or label can greatly reduce the requirements of protein engineering, so that the challenging IMPs can be carried out in a more natural state. the study. Like all Agile R100 biosensors, FLEX chips are renewable and cost effective. The single-sample format of the Agile R100 allows researchers to apply samples directly to the sensor surface to reduce protein degradation during the process.

Ross Bundy added: "In addition to providing a convenient method for studying IMPs, the new FLEX chip accelerates the development of all cell-based assays, including whole-cell analysis. Its uniform hydrophobic surface is suitable for whole-cell growth. Conditions, so researchers don't have to face challenging surface chemistry studies to immobilize target proteins. Our goal is to make it easier for researchers to characterize the interactions required to convert in vitro activity into in vivo efficacy."

The Agile R100 is the world's first dynamic characterization platform built using proprietary field-effect biosensing (FEB) technology, a breakthrough electronic technology for real-time measurement of biomolecular interactions. The easy-to-use, one-sample format provides economical, reliable, and informative data for all laboratories, and provides a cost-effective way to verify target accuracy and improve drug discovery efficiency.


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